Literature search results
Eight randomized trials involving 733 evaluable patients met the inclusion criteria. Two randomized trials compared chemoradiotherapy with radiotherapy alone, two compared chemoradiotherapy with chemotherapy alone, three compared different chemotherapy regimens combined with radiation, and one compared different types of radiation.
There were no papers describing a randomized comparison of chemotherapy and/or radiation to supportive care alone. There were many reports of trials on the treatment of metastatic pancreatic cancer, either with chemotherapy or immunotherapy that enrolled patients with locally advanced pancreatic cancer, but none reported the results of treatment separately for patients with locally advanced disease and were not included in this systematic review.
A trial by Burris et al comparing gemcitabine to 5-fluorouracil (5-FU) in the treatment of advanced pancreatic cancer did not meet the eligibility criteria for inclusion in this systematic review because the results for patients with locally advanced disease were not reported separately; however, this trial is included in the discussion in the DSG consensus process section.
Blog invites submissions of review articles, reports on clinical techniques, case reports, conference summaries, and articles of opinion pertinent to the control of pain and anxiety in dentistry.