The treatment of locally advanced pancreatic cancer: METHODS (Part 1)

In: Pancreatic cancer

14 Jul 2012

Guideline development

This practice guideline report was developed by the Cancer Care Ontario Practice Guidelines Initiative (CCOPGI) using the methodology of the Practice Guidelines Development Cycle. Evidence was selected and reviewed by three members of the CCOPGI’s Gastrointestinal Cancer Disease Site Group (DSG) and methodologists. Members of the Gastrointestinal Cancer DSG disclosed potential conflict of interest information.

The practice guideline report is a convenient and up-to-date source of the best available evidence on the treatment of locally advanced pancreatic cancer, developed through systematic reviews, evidence synthesis and input from practitioners in Ontario. The report is intended to enable evidence-based practice. The Practice Guidelines Initiative is editorially independent of Cancer Care Ontario and the Ontario Ministry of Health and Long-Term Care.

The CCOPGI has a formal standardized process to ensure the currency of each guideline report. This consists of periodic review and evaluation of the scientific literature and, where appropriate, integration of this literature with the original guideline information.

Literature search strategy

MEDLINE (January 1966 to March 2002), CANCERLIT (January 1983 to October 2001), and the Cochrane Library (2002, Issue 1) were searched with no language restrictions. ‘Pancreatic neoplasms’ (Medical subject heading [MeSH]) was combined with ‘chemotherapy, adjuvant’ (MeSH), ‘radiotherapy’ (MeSH), and ‘immunotherapy’ (MeSH), and each of the following phrases used as text words: ‘chemotherapy’, ‘radiotherapy’, ‘radiation’, and ‘immunotherapy’. These terms were then combined with the search terms for the following study designs or publication types: practice guidelines, meta-analyses and randomized controlled trials.

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