The N-Terminus of the Atrial Natriuretic Factor Prohormone in the Pleural Fluid of Congestive Heart Failure Patients: Results

In: Congestive Heart Failure

1 Nov 2012

The concentrations of immunoreactive pro ANF 198 (whole N-terminus) and ir pro ANF 31-67 (midportion of the N-terminus) in the pleural fluid of each of six individuals with New York Heart Association (NYHA) class 2 congestive heart failure are shown in Figure 1. The mean concentration of pro ANF 1-98 in the pleural fluid of these patients was 1631 ± 147 finol/ ml (SEM). The average concentration of pro ANF 3167 in their pleural fluids was 1,690 ± 199 fmol/ml. The respective circulating concentrations of the whole N-terminus and pro ANF 31-67 in each of these same individuals is also illustrated in Figure 1. It is important to note that the concentrations of the whole N-terminus of the ANF prohormone and pro ANF 31-67 in pleural fluid were almost as high as their concentrations in plasma. This finding is similar to ANF (C-terminus of prohormone) whose concentration in pleural fluid and in the circulation was found to be nearly equal in these same patients.
The mean concentrations of pro ANF 1-98 and pro ANF 31-67 in the circulation of these patients with class 2 NYHA congestive heart failure were 1,682 ± 146 fmol/ml and 1,832 ±227 fmol/ml, respectively. These plasma concentrations are significantly higher (p<0.001) than that of persons without congestive heart failure, with our normal range for the whole N-terminus of the prohormone being 506 to 556 fmol/ml while the circulating concentration of pro ANF 3167 in 54 persons without congestive heart failure has been found to be 371 ± 18 fmol/ml. ventolin inhaler

Figure_1

Figure 1. Comparison of the concentration of pro ANF 1-98 (the N-terminus of the ANF prohormone) and pro ANF 31-67 in the pleural fluid and plasma of six congestive heart failure patients. The normal range for pro ANF 1-98 (• closed circles) and pro ANF 3167 m closed squares) in plasma of 54 persons without congestive heart failure is indicated by the respective boxes in this figure. The concentration of both pro ANF 1-98 and pro ANF 31-67 in the pleural fluid and plasma of congestive heart failure patients was significantly higher (p<0.001) than that in the plasma of persons without congestive heart failure when analyzed by the Students t-test for unpaired values. 


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