The N-Terminus of the Atrial Natriuretic Factor Prohormone in the Pleural Fluid of Congestive Heart Failure Patients: Discussion (Part 5)

In: Congestive Heart Failure

6 Nov 2012

The N-Terminus of the Atrial Natriuretic Factor Prohormone in the Pleural Fluid of Congestive Heart Failure Patients: Discussion (Part 5)A similar study with the natriuretic peptides derived from N-terminus of the ANF prohormone has not yet been done. Whether or not the secretion of these natriuretic and diuretic peptides from the N-terminus and C-terminus of the ANF prohormone into the pleural fluid helps the lung clear the fluid in the lung in CHF, in addition to these peptides known effects of increasing salt and water diuresis by their actions on the kidney, await further investigation. It is of interest in this regard that postcapillary venule leakage is generally caused by agents that induce smooth muscle contraction and is inhibited by agents with smooth muscle relaxant properties. Pro ANFs 1-30 and 3167 from the N-terminus and ANF are endogenous peptides with vascular smooth muscle relaxing properties. Their presence in increased quantities in the circulation of congestive heart failure patients as found in the present investigation should help to reverse the increased permeability of capillaries and postcapillary venules if smooth muscle vascular contraction is indeed the cause of increased capillary permeability. The smooth muscle relaxing properties of these newly discovered peptides from the N-terminus and C-terminus of the ANF prohormone should help to decrease edema formation in the lung (and elsewhere in the body) if smooth muscle contraction resulting in a larger pore opening between these cells in the vasculature is the cause of the increased capillary permeability. birth control pills


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