In: Crohn's disease30 Jul 2012
Demographic characteristics of the patients with normal serum 25-OHD and those with serum 25-OHD deficiency are given in Table 1. Of the 242 consecutive patients assessed at baseline, 19 (8%) were found to have a serum 25-OHD of less than 25 nmol/L. Of those patients with 25-OHD deficiency, 11 (57.9%) were osteopenic, one (5.3%) was osteoporotic and seven (36.8%) had normal BMD. These BMD results did not differ significantly from the prevalence of low BMD in the non-25-OHD deficient Crohn’s disease cohort (48.6% osteopenia and 14.2% osteoporosis, P>0.05). In the 25-OHD deficient patients, decreased bone mineral density was most pronounced at the femoral neck and lumbar spine (47.4% and 42.1%, respectively).
This distribution of decreased bone mineral density did not differ from that of patients with normal levels of 25-OHD (51.9% femoral neck and 46.1% lumbar spine, P>0.05). Age at baseline, disease duration, BMI, corticosteroid use, and disease location did not differ between the deficient and normal 25-OHD group. There were a greater percentage of smokers in the 25-OHD deficient group than in the normal group (62.5% and 35.6%, respectively); however, this difference did not show statistical significance (%2=5.929, P=0.115). Choosing a fine online pharmacy where you can buy efficient medications is not an easy task, but now it is not a difficult one either. Soon you will have a chance to buy cialis online pharmacy buy here in just a few minutes of your time without having to worry about anything, and this does sound like a great thing to have.
TABLE 1 Demographic characteristics of 19 patients with Crohn’s Disease and serum 25-hydroxyvitamin D3 (25-OHD) deficiency, compared with 219 Crohn’s disease patients with normal serum 25-OHD
|Age (years) Mean ± SD||38.5±12.4||40.4±10.0|
|Age at diagnosis (years) Mean ± SD||27.2±12.0||30.3±9.9|
|Years since Crohn’s disease diagnosis||11.3±8.7||10.1±8.9|
|Mean ± SD|
|Crohn’s disease location:||(% of patients)||(% of patients)|
|Colon and ileum||40.1||41.2|
|% smokers (at any time)||35.6||62.5|
|BMI (kg/m2) (Mean ± SD)||24.9±4.6||27.1±4.6|
|Number of flares requiring|
|a physician’s visit in last year||(% of patients)||(% of patients)|
|Patients who used steroids in last year (%)||51.6||47.4|
|Patients with normal bone density (%)||37.2||36.8|
|Patients with osteopenia (%)||48.6||57.9|
|Patients with osteoporosis (%)||14.2||5.3|
25-OHD deficiency is defined as a serum 25-OHD concentration below 25 nmol/L. BMI Body mass index; F Female; M Male
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