In: Crohn's disease27 Jul 2012
Between 1998 and 2000, 224 patients with Crohn’s disease who had attended the Inflammatory Bowel Disease Research Centre and Clinic, at the University of Alberta Hospital, Edmonton, Alberta, were consecutively enrolled in a prospective longitudinal investigation to assess the clinical efficacy of bisphosponate therapy on bone mineral density in Crohn’s disease patients. An additional 18 patients from Mount Sinai Hospital, Toronto, Ontario, were also enrolled, giving a total of 242 patients. Data relevant to vitamin D were gathered at baseline assessment. Informed consent from each patient was received in writing before being enrolled. Crohn’s disease and the site of the disease was diagnosed on the basis of endoscopic, radiological and histological examination. Those patients with a serum 25-OHD concentration below 25 nmol/L were classified as being vitamin D deficient and were separately analyzed for the purposes of this study.
The following exclusion criteria were applied at baseline: age less than 18 years; patients with known bone disorders other than osteoporosis (such as hyperparathyroidism, Paget’s disease, renal osteodystrophy and documented osteomalacia); patients with abnormal thyroid function; patients with significant renal impairment (serum creatinine twice the normal level); patients with clinical short bowel syndrome; patients on total parenteral or enteral nutrition; and patients with spinal anatomy that did not allow adequate assessment with dual energy x-ray absorptiometry (DEXA, Hologic 4500, Hologic Inc, USA). In addition, patients who had received bisphosphonate or fluoride supplement in the 24 months before the data collection or pharmacological doses of calcium (greater than 1.0 g/day) or vitamin D (greater than 800 IU/day) in the six months before entry were excluded from the study. You will always be able to find cialis professional shopping with a trusted foreign pharmacy.
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