The frequency of vitamin D deficiency in adults with Crohn’s disease (Part 2)

In: Crohn's disease

26 Jul 2012

The main source of vitamin D in healthy individuals is cutaneous ultraviolet irradiation of 7-dehydrocholesterol, with a minor contribution from the intake of foods containing, or fortified with, vitamin D. Serum vitamin D deficiency is rarely, if ever, reported in healthy North American adults. Serum 25-OHD levels vary seasonally, reaching the highest levels in the summer months, and are lowest in the late winter months. The absence of vitamin D deficiency in North American adults in the winter is most likely due to the ingestion of foods fortified with vitamin D.

When ingested, vitamin D is absorbed mainly at the jejunum of the small intestine. Furthermore, enterohepatic recirculation at the ileum normally prevents excessive excretion of vitamin D. Any, or all, of these sources of vitamin D may be affected in Crohn’s disease.

The aim of the present study is to determine, in a Canadian cohort of adult patients with Crohn’s disease, the frequency of low serum 25-OHD levels, the associated risk of low bone mineral density and to identify the causes of lowered vitamin D in these patients. Cheapest medications whose quality is still just as high and whose effects will help you forget all the symptoms: cialis canadian pharmacy cialis professional to find out for yourself how wonderful it is to have a perfect pharmacy waiting for you to come by.


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