The frequency of vitamin D deficiency in adults with Crohn’s disease: DISCUSSION (Part 3)

In: Crohn's disease

6 Aug 2012

secondary hyperparathyroidism

Nevertheless, it does appear that a deficiency in 25-OHD did have adverse effects on bone metabolism. Patients with low serum 25-OHD experienced a higher mean alkaline phosphatase and serum PTH, when compared to the patients with normal 25-OHD levels. Similar findings have been previously reported in other studies. It has been recognized that secondary hyperparathyroidism, as a consequence of 25-OHD deficiency, along with an increase in bone formation rate mark the beginnings of 25-OHD deficiency-induced metabolic bone disease, which is often asymptomatic and subclinical. Furthermore, a long term borderline 25-OHD serum level will contribute to a nutritional deficiency disorder resulting in osteoporosis.

25-OHD deficiency may occur in patients with Crohn’s disease for a number of reasons, including low sunlight exposure, malabsorption and reduced vitamin D intake. In this study, very few patients demonstrated low 25-OHD in the summer months. Indeed, only three of the 108 patients who were assessed between April and September exhibited low serum 25-OHD, two of them being assessed in the first week of April. This observation is in agreement with the accepted notion that skin generation of 25-OHD through sunlight exposure is likely a significant source of 25-OHD in patients with Crohn’s disease. Low serum RBC folate levels was predictive of 25-OHD deficiency in both males and females. Furthermore, patients with low serum 25-OHD exhibited lower albumin and carotene levels than those with normal levels of circulating 25-OHD. These findings imply that nutritional status, possibly related to the dietary intake of foods fortified with 25-OHD, plays an important role in determining 25-OHD deficiency in our patients with Crohn’s disease. You will always come across discount levitra online cialis professional 20 mg at a pharmacy that will offer best deals.


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