The frequency of vitamin D deficiency in adults with Crohn’s disease: DISCUSSION (Part 2)

In: Crohn's disease

5 Aug 2012

It is conceivable that our results represent an under-reporting of the incidence of 25-OHD-deficiency. Our study observed that the majority of patients exhibiting deficient serum levels had their 25-OHD levels assessed during the winter months (84.1%), yet the total distribution of measurements was equal between the winter and summer months. We would have expected a higher incidence of serum 25-OHD deficiency if all measurements were carried out within a specified time period during the winter months. In fact, when only those patients who had been assessed for vitamin D status during the winter months were considered, almost 12% demonstrated 25-OHD deficiency.

Our results further demonstrated that there was a four-fold higher probability of 25-OHD deficiency if patients were assessed in the winter months, rather than in the summer. This would concur with the results of Vogelsang et al, who observed that 25-OHD levels in Crohn’s disease patients were higher in the summer than in the winter and that of the patients with low 25-OHD levels in the winter, less than half continued to exhibit low levels in the summer.

Our study confirms previous reports that serum levels of 25-OHD do not correlate with, or predict, bone mineral status in patients with Crohn’s disease. Furthermore, while 63% of patients with deficient serum 25-OHD exhibited low BMD, this frequency did not differ from the study population with normal levels of 25-OHD. This has led to the conclusion that factors other than 25-OHD insufficiency may be primarily responsible for the increased incidence of osteopenia and osteoporosis in patients with Crohn’s disease. Your drugs could cost a lot less money and take less time to get: buy clomiphene cialis professional 20 mg to find out what it feels like to be able to start your treatment without thinking about prescriptions and other factors like that.


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