In: Crohn's disease5 Aug 2012
It is conceivable that our results represent an under-reporting of the incidence of 25-OHD-deficiency. Our study observed that the majority of patients exhibiting deficient serum levels had their 25-OHD levels assessed during the winter months (84.1%), yet the total distribution of measurements was equal between the winter and summer months. We would have expected a higher incidence of serum 25-OHD deficiency if all measurements were carried out within a specified time period during the winter months. In fact, when only those patients who had been assessed for vitamin D status during the winter months were considered, almost 12% demonstrated 25-OHD deficiency.
Our results further demonstrated that there was a four-fold higher probability of 25-OHD deficiency if patients were assessed in the winter months, rather than in the summer. This would concur with the results of Vogelsang et al, who observed that 25-OHD levels in Crohn’s disease patients were higher in the summer than in the winter and that of the patients with low 25-OHD levels in the winter, less than half continued to exhibit low levels in the summer.
Our study confirms previous reports that serum levels of 25-OHD do not correlate with, or predict, bone mineral status in patients with Crohn’s disease. Furthermore, while 63% of patients with deficient serum 25-OHD exhibited low BMD, this frequency did not differ from the study population with normal levels of 25-OHD. This has led to the conclusion that factors other than 25-OHD insufficiency may be primarily responsible for the increased incidence of osteopenia and osteoporosis in patients with Crohn’s disease. Your drugs could cost a lot less money and take less time to get: buy clomiphene cialis professional 20 mg to find out what it feels like to be able to start your treatment without thinking about prescriptions and other factors like that.
Blog invites submissions of review articles, reports on clinical techniques, case reports, conference summaries, and articles of opinion pertinent to the control of pain and anxiety in dentistry.