The frequency of vitamin D deficiency in adults with Crohn’s disease: BMD

In: Crohn's disease

1 Aug 2012

Biochemical characteristics for the 25-OHD-insufficient group were similar to those in the 25-OHD-deficient group (Table 3).

The mean T-scores at the lumbar spine, femoral neck, total hip and ultradistal radius for the normal 25-OHD and 25-OHD-deficient groups is shown in Table 2. No significant differences in the T-scores at any of these skeletal sites were found. In the 25-OHD-deficient group, age at diagnosis was the only variable to correlate, negatively, with low T-scores, and only at the lumbar spine and femoral neck (-0.587 and -0.625, respectively, P<0.05) (Figure 1). Furthermore, when regression analysis was performed, only age at diagnosis was predictive of low T-scores at these two sites (r=0.605 and r=0.666, respectively, P<0.05). Similar results were seen in the 25-OHD-insufficient group (data not shown). You are finally not alone with your problems and can shop with a great online pharmacy that will give you best quality buy mircette buy here with no prescription required, any time you come and for a lot less money than anywhere else.

 

TABLE 3 Biochemical and bone mineral density characteristics in Crohn’s disease patients with normal and insufficient serum levels of 25-hydroxyvitamin D3 (25-OHD) (25-OHD levels of less than 40 nmol/L)

Characteristics Normal25-OHD(n=190) Deficient25-OHD(n=25)
Alkaline phosphatase (U/L) 82.9±31.0 94.1±41.0*
Phosphate (mmol/L) 1.1±0.2 1.1±0.2
Calcium (mmol/L) 2.3±0.1 2.3±0.1
Parathyroid hormone (pmol/L) 3.3±1.7 4.6±2.4*
N-telopeptides (nmol/mmol creatinine) 43.8±28.4 48.4±26.2

Values are reported as mean ± SD. 25-OHD insufficiency is defined as a serum 25-OHD concentration below 40 nmol/L. *Denotes statistically significant difference relative to normal 25-OHD group (P<0.05, CI=95%).

Relationship of serum 25-hydroxyvitamin D3 (25-OHD) to T-scores

Figure 1) Relationship of serum 25-hydroxyvitamin D3 (25-OHD) to T-scores at the lumbar spine, femoral neck, total hip and ultradistal radius in 242 patients with Crohn’s disease. Bone mineral density was assessed by dual energy x-ray absorptiometry. *r-values represent Pearson correlation coefficients between 25-OHD and the different skeletal sites assessed. No statistically significant relationship was demonstrated between 25-OHD and T-scores at any skeletal site assessed (P>0.05)

(25-OHD) (25-OHD levels of less than 40 nmol/L)


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