The frequency of vitamin D deficiency in adults with Crohn’s disease: BMD

In: Crohn's disease

1 Aug 2012

Biochemical characteristics for the 25-OHD-insufficient group were similar to those in the 25-OHD-deficient group (Table 3).

The mean T-scores at the lumbar spine, femoral neck, total hip and ultradistal radius for the normal 25-OHD and 25-OHD-deficient groups is shown in Table 2. No significant differences in the T-scores at any of these skeletal sites were found. In the 25-OHD-deficient group, age at diagnosis was the only variable to correlate, negatively, with low T-scores, and only at the lumbar spine and femoral neck (-0.587 and -0.625, respectively, P<0.05) (Figure 1). Furthermore, when regression analysis was performed, only age at diagnosis was predictive of low T-scores at these two sites (r=0.605 and r=0.666, respectively, P<0.05). Similar results were seen in the 25-OHD-insufficient group (data not shown). You are finally not alone with your problems and can shop with a great online pharmacy that will give you best quality buy mircette buy here with no prescription required, any time you come and for a lot less money than anywhere else.


TABLE 3 Biochemical and bone mineral density characteristics in Crohn’s disease patients with normal and insufficient serum levels of 25-hydroxyvitamin D3 (25-OHD) (25-OHD levels of less than 40 nmol/L)

Characteristics Normal25-OHD(n=190) Deficient25-OHD(n=25)
Alkaline phosphatase (U/L) 82.9±31.0 94.1±41.0*
Phosphate (mmol/L) 1.1±0.2 1.1±0.2
Calcium (mmol/L) 2.3±0.1 2.3±0.1
Parathyroid hormone (pmol/L) 3.3±1.7 4.6±2.4*
N-telopeptides (nmol/mmol creatinine) 43.8±28.4 48.4±26.2

Values are reported as mean ± SD. 25-OHD insufficiency is defined as a serum 25-OHD concentration below 40 nmol/L. *Denotes statistically significant difference relative to normal 25-OHD group (P<0.05, CI=95%).

Relationship of serum 25-hydroxyvitamin D3 (25-OHD) to T-scores

Figure 1) Relationship of serum 25-hydroxyvitamin D3 (25-OHD) to T-scores at the lumbar spine, femoral neck, total hip and ultradistal radius in 242 patients with Crohn’s disease. Bone mineral density was assessed by dual energy x-ray absorptiometry. *r-values represent Pearson correlation coefficients between 25-OHD and the different skeletal sites assessed. No statistically significant relationship was demonstrated between 25-OHD and T-scores at any skeletal site assessed (P>0.05)

(25-OHD) (25-OHD levels of less than 40 nmol/L)

About this blog

Blog invites submissions of review articles, reports on clinical techniques, case reports, conference summaries, and articles of opinion pertinent to the control of pain and anxiety in dentistry.