The enteric nervous system in inflammation and pain: NEUROGENIC INFLAMMATION IN THE GUT

In: Enteric nervous system

9 Aug 2012

Vasodilation and increased vascular permeability are observed in response to CGRP and substance P release, through direct endothelial activation of the type I CGRP receptor and the neurokinin-1 receptor (NK-1), respectively. Activation of endothelial receptors for CGRP and NK-1 causes not only extravasation of plasma from the blood into the tissues, but also facilitates the recruitment of inflammatory cells (Figure 1). Moreover, enteric neurons can stimulate mast cell degranulation by the release of substance P (Figure 1).

Mast cell degranulation causes the release of numerous inflammatory mediators: cytokines, proteinases, nitric oxide and lipid mediators of inflammation, including prostaglandins, leukotrienes and thromboxane. Those molecules stimulate other inflammatory cells, such as macrophages, neutrophils and lymphocytes, which can then further promote the release of neuropeptides from enteric nerves, thereby amplifying the inflammatory response (Figure 1).

Interactions of the enteric nervous system (ENS) with components of the inflammatory process

Figure 1) Interactions of the enteric nervous system (ENS) with components of the inflammatory process. Upon activation by noxious agents, the ENS (both extrinsic and intrinsic enteric nerves) release neuropeptides (substance P [SP] and calcitonin gene-related peptide [CGRP]) that, by acting on vascular endothelium, cause vasodilation and increased vascular permeability, two major features of the inflammatory reaction. Neuropeptides such as SP also provoke mast cell activation/degranulation, which subsequently activates the other actors of inflammation: vascular endothelium, macrophages, lymphocytes and neutrophils, through the release of various inflammatory mediators (cytokines, prostaglandins [PGs], leukotrienes [LTs], proteinases and nitric oxide [NO]). Inflammatory cells could, in turn, further induce the ENS to release neuropeptides, thus amplifying the inflammatory reaction. Through the release of vasoactive intestinal peptide (VIP), enteric neurons can also interact with inflammatory cells. Activation of nociceptive enteric neurons also conveys nociceptive information, especially pain, to the central nervous system You will always find generic tadalafil online , shopping online with pleasure every time.

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