Study Method
There are several reports on observations of anesthetic potency of local anesthetics in the teeth. Previous animal models that have been used to study the effects of local dental anesthetics involved the use of the method of Buldring et al, in which the skin contraction response was measured, and the Herr and Jones procedure, [...]

The results are summarized in Tables 1 and 2 and Figure 3.
Comparison of the ED50 Values
When the potency of the test anesthetics was compared, we found that the A6 group compared with the L group showed a 2.8 times potency 5 and 10 minutes after administration. The ED50 of the A12 group was the lowest [...]

Subjects and Method of Observation of Anesthetic Effect
The subjects studied were 35 male Japan White rabbits weighing between 1.9 and 2.1 kg. This study was conducted in compliance with the Guidelines for the Treatment of Experimental Animals at the Tokyo Dental College and in accordance with the guidelines of the Japanese government. A 22-gauge in-dwelling [...]

Only a few studies on the potency of the various local anesthetics have been reported because of the lack of an appropriate experimental model. We tested the potency of 4 types of local anesthetics extraorally and measured the response of the rabbit digastric muscle, which relates to jaw-opening reflex, by electromyogram (EMG) at various points [...]