In: Main
25 Jun 2010Table 5 lists all treatment-related clinical adverse events that occurred in 3% or more of the Hepsera™-treated patients compared with those receiving placebo. Increased asthenia, headache, and abdominal pain are the most frequently reported adverse events, followed by nausea and flatulence. Two other less commonly reported side effects are diarrhea and dyspepsia.
In: Main
24 Jun 2010From a 10-mg single dose of Hep-sera™, the approximate bioavailability of adefovir is 59%. After oral administration of a 10-mg single dose of Hepsera™ to patients with chronic hepatitis B, the peak adefovir plasma concentration has been 18.4 + 6.26 ng/ml, occurring between 0.58 and 4.00 hours after a dose. The adefovir area under the [...]
In: Main
23 Jun 2010INTRODUCTION
The leading cause of cirrhosis and hepatocellular carcinoma around the world is chronic hepatitis B virus (HBV) infection. Approximately 10% of patients who carry the human immunodeficiency virus (HIV) in the U.S. are co-infected with HBV and face decreased survival rates. Worldwide, 400 million people are chronically infected with hepatitis B.
In: Drug
19 Jun 2010date, no therapeutic drug concentrations of aripiprazole have been established. Although quantitative data are limited with respect to the drug’s bio-availability, Yokoi et al. reported that administration of tablet aripiprazole for 14 days in 15 males, in doses of 0.5, 1, 2, 10, and 30 mg/day, resulted in dose-dependent receptor occupancy between 40% and 95%. [...]
In: Drug
18 Jun 2010Although minimal side effects from aripiprazole table have been reported, complete clinical data have not yet been established. In a 52-week study reported by Bristol-Myers Squibb, 1,294 patients with schizophrenia were evaluated to establish efficacy, safety, and tolerabil-ity. Patients taking aripiprazole experienced significantly fewer extrapyramidal symptoms than patients taking haloperi-dol. The most commonly reported adverse [...]
In: Drug
17 Jun 2010INTRODUCTION
Although early antipsychotic agents, such as chlorpromazine drug (Thorazine tablet, GlaxoSmithKline) and haloperidol (Haldol®, Ortho-McNeill) showed great promise initially, their limitations became evident when extrapyramidal side effects were associated with their use. Subsequently, the novel atypical antipsychotics, such as generic clozapine (Clozaril drug, Novartis), risperidone drug (Risperdal canadian, Janssen), canadian olanzapine (Zyprexa generic, Eli Lilly), [...]
In: Drug
11 Jun 2010Clinical studies involving enfuvirtide are limited. No clinically significant drug interaction was reported when this medication was used in combination with the other antiretroviral drugs. In cell culture media assays, enfuvirtide exhibited additive-to-synergistic effects when it was combined with individual members of various antiretroviral agents, such as zidovudine (AZT, Retrovir drug, (Glaxo-SmithKline), lamivudine generic (3TC, [...]
Blog invites submissions of review articles, reports on clinical techniques, case reports, conference summaries, and articles of opinion pertinent to the control of pain and anxiety in dentistry.