The occurrence of allergic reaction to epinephrine is very rare. A few cases of allergic reaction to epinephrine preparations in ophthalmic and dermatologic regions have been reported. It is unusual to employ allergy testing to specific responses to epinephrine with local anesthesia in the dental clinic setting. According to these reports, the epinephrine preparation or [...]

Epinephrine preparations are composed of artificial chemical products that have the same chemical and pharmacokinetic characteristics as endogenous epinephrine in vivo. Local anesthetics with epinephrine are commonly used in dentistry to provide effective anesthesia, good hemostasis, and to prevent toxic reaction to local anesthetics. Systemic complications to local anesthetics with epinephrine are well documented, but [...]