There is now general acceptance that extragonadal germ cell tumors, particularly pineal and mediastinal sites, represent malignant transformation of germinal elements distributed to these sites without a gonadal primary focus. Some investigators suggest that this distribution arises as a consequence of abnormal migration of germ cells during embryogenesis. Others have suggested that there is widespread distribution of germ cells to liver, thymus, bone marrow, and brain during normal embryogenesis and […]
Mediastinal germ cell tumors have long been the subject of fascination for pathologists and developmental biologists as well as a subject of controversy for clinicians. Speculations regarding etiology have ranged from the opinion that these tumors are really of gonadal origin and represent spread from an occult or “burned out” primary […]
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