Careful physical examination of the testis should be supplemented by testicular ultrasonography when abnormalities are present or if there is significant retroperitoneal adenopathy suggesting a testicular primary. There is no role for blind orchiectomy or testicular biopsy in patients with a normal testicular examination and ultrasound. Other investigations such as brain […]
Laboratory Findings: Measurement of serum tumor markers, beta subunit human chorionic gonadotropin, alphafetoprotein, and lactate dehydrogenase is indispensable in the management of mediastinal germ cell tumors. Patients with benign teratoma, by definition, are marker negative and significant elevations of HCG or AFP implies a malignant component to the tumor. Primary mediastinal seminoma can be associated with low level elevation of HCG (usually less than 100 mlU/ ml), but significant elevation […]
Physical Findings: Patients with mediastinal germ cell tumors have few abnormal physical findings. In patients with large tumors, decreased breath sounds, and dullness on the affected side may be encountered. Tumor extension to the pericardium or throughout the mediastinum can produce pericardial or […]
Clinical Presentation: The symptoms that prompt medical attention in patients with mediastinal germ cell tumors are, in part, dependent upon the histologic subtype. Benign teratomas are frequently discovered on chest roentgenography while the patient is asymptomatic. When symptoms of benign teratoma are present, these are frequently symptoms of local growth of the tumor within the anterior superior mediastinum. Chest pain, dyspnea, and cough occur frequently. Less commonly, patients can develop […]
Of the 107 patients with primary testis tumors, eight were from racial minorities (Hispanic, five; Asian-American, one; African-American, one; American Indian, one). Review of other series of mediastinal germ cell tumors likewise suggests that racial minorities are over-represented relative to the incidence of testicular cancer among these minorities.’ buy flovent inhaler
Gonadal germ cell tumors are extremely rare among minorities. The recent Surveillance Epidemiology and End Results program for the years 1973 to 1982 revealed that 90.4 percent of cases of testicular germ cell cancers occurred in whites, 2.1 percent in blacks, 6.2 percent in Hispanics, and 1.3 percent in the category of others which included Japanese, Chinese, and patients of unspecified ethnicity. The peak incidence of testicular cancer for adult […]
Within the subset of germ cell neoplasms, mediastinal germ cell tumors account for only one to three percent of all germinal tumors. However, mediastinal germ cell tumors represent the most common extragonadal primary site and account for 50 to 70 percent of all germ cell tumors in most adult series. Mediastinal […]
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