Posts Tagged ‘heartburn

The study groups were relatively small in most of the reports. Only four studies had more than 20 subjects who completed the protocol (Table 1). This raises concerns that a beta error may have masked a beneficial effect of medical antireflux therapy. The average change in FEV1 in these studies was less than 5%, with an SD of approxi mately 30%. The required sample size, with an alpha of 0.05 […]

Does Medical Antireflux Therapy Improve Asthma in Asthmatics With Gastroesophageal Reflux: Alternative HypothesesThese studies may have been too short to allow the complete benefit from antireflux therapy to become apparent. One surgical series presented 5-year follow-up data indicating an improvement in lung function. One half of the patients in […]

Because there have been relatively few studies using each antireflux medication, all of the English-language, peer-reviewed, placebo-controlled studies of the effects of antireflux medication on asthma were combined for analysis. The inclusion of studies using the different antireflux regimens is justified by the similarity of their outcomes. The combined data show that the majority of patients experienced an improvement in asthma symptoms and their asthma medication requirements decreased, even though […]

Does Medical Antireflux Therapy Improve Asthma in Asthmatics With Gastroesophageal Reflux: AnalysisThe subjects were divided into treatment responders and nonresponders. Improvement was defined by the presence of at least one of the following: asthma symptom score reduction of more than 20%, PEF improvement by more than 20%, total number of […]

Ford et al studied the effects of omeprazole, 20 mg daily for 4 weeks, in 11 patients with both asthma and GER in a randomized, double-blind, placebo-controlled, crossover protocol. There was a 1-week run-in period at the beginning of the study and a 1-week washout period between treatment periods. No improvement in GER or asthma symptoms, bronchodilator use, or PEFR was found in this relatively low-dose, short-term study of only […]

Does Medical Antireflux Therapy Improve Asthma in Asthmatics With Gastroesophageal Reflux: RanitidineFifteen patients with asthma and GER were treated with ranitidine, 450 mg daily for 7 days in a blinded, crossover, placebo-controlled study with only a 3-day washout period between treatments The treatment period was too short for GER symptoms […]

Conservative Therapy Including Alginates
Kjellen et al randomized patients with asthma and esophageal dysfunction, as evidenced by symptoms and abnormal manometry and/or a positive AP test, to receive either conservative therapy including alginates or no treatment. Untreated patients were given neither advice nor medication for their esophageal symptoms. After 2 months, 87% of the treatment group and 11% of the nontreatment group reported relief or improvement of their esophageal […]

Pages: 1 2 Next

About this blog

Blog invites submissions of review articles, reports on clinical techniques, case reports, conference summaries, and articles of opinion pertinent to the control of pain and anxiety in dentistry.