Like the delayed-release, enteric-coated, oral PPI formulations, IR-OME may prolong the elimination of drugs that are metabolized by oxidation in the liver, such as diazepam (Valium, Roche), warfarin generic (Coumadin candian, Bristol-Myers Squibb), and generic phenytoin (Dilantin drug, Pfizer). Increased International Normalized Ratios (INRs) and prothrombin times have been reported in patients receiving concomitant warfarin [...]

PROTON PUMP INHIBITORS: AN OVERVIEW
Acid-related disorders encompass a wide variety of diagnoses, including the extremely prevalent gastroesophageal reflux disease (GERD), which affects an estimated 25 million Americans, duodenal and gastric ulceration, stress-related mucosal disease, and acute upper gastrointestinal bleeding, a common medical emergency resulting in approximately 300,000 hospitalizations annu-ally. During the last three decades, the management [...]