The encouraging combination of these 2 relatively short-acting agents with similar pharmacokinetics and complimentary pharmacological properties, which lacks ketamine’s adverse reactions, has been clearly substantiated.
Midazolam is the benzodiazepine of choice when combined with ketamine in terms of physiological homeostasis and recovery time.

Oxygen saturation levels remained high at approximately 99%. Respiration rate did not alter significantly from baseline levels throughout the study period.

Ten healthy individuals with a mean age of 29 years and a mean weight of 64 kg were enrolled. The study was approved by the institution’s human investigation committee, and written informed consent was obtained from all subjects. All subjects were ASA physical status I without psychiatric and psychological conditions and were not using any [...]

The ideal sedative is one that safely provides relief from pain, anxiety, and unpleasant memories for a wide variety of procedures. In reality there are few such agents; hence the need for a combination of agents. The subhypnotic administration of IV anesthetics during local or regional anesthesia is becoming more common. The technique of combining [...]