Posts Tagged ‘Cytokines

The findings of this investigation allow us to make two important clinical observations. First, as in other reports, our results allude to the higher elucidation of TNFa in patients with chronic heart failure, even in the absence of cachexia. Second, and more importantly, we were unable to demonstrate a significant improvement in elaboration of TNFa […]

TNFa in CHF Patients and Control Subjects The mean concentration of TNFa in the normal control subjects was 0.89±0.40 pg/mL (range, 0.5 to 9.7 pg/mL) and was above the limit of detection (>0.5 pg/mL) in 8 subjects. Plasma concentrations of TNFa in acutely decompensated CHF patients were significantly higher (p<0.002) at 3.0±0.4 pg/mL (range, 0.5 […]

Study Population The study population consisted of 29 noncachectic patients (20 men and 9 women; age range, 27 to 79 years; mean 56 ±13 years) with advanced CHF who demonstrated acute decompensation while receiving adequate oral medical therapy, thus requiring admission to the hospital for therapeutic intervention. Patients were excluded if they exhibited any evidence […]

Study objective: To evaluate the clinical relevance of circulating tumor necrosis factor-a (TNFa) in subjects with advanced acutely decompensated congestive heart failure (CHF) and to determine the modulatory effect of clinical interventions on short-term elaboration of this cytokine. Design: Prospective, case-controlled study. Setting: Inpatient and outpatient (hospital and clinic), at regional academic medical center. Patient […]

A study by Dong et al has provided further evidence that attenuation of apoptosis may facilitate tumour progression in colon cells. Dong et al examined the role of cytosolic phospholipase A2 (cPLA2) in TNF-a-induced apop-tosis of cultured mouse colonocytes. The specific cPLA-2 inhibitor, AACOCF-3 (arachidonoyl trifluoromethyl ketone), was able to protect colonocytes from TNF-a-induced apoptosis […]

Apoptosis is an important regulatory mechanism by which unwanted cells are eliminated in tumourigenesis. Apoptosis is initiated by binding of death receptors such as Fas, TNF-R and TRAIL-R to their ligands. Binding of the receptors results in transmission of apoptotic signals and the activation of enzymatic caspase complexes . IFNs function in the apoptotic pathway […]

Normal colonic epithelial cells are dependent on cell-cell adhesion and survival factors for the inhibition of apoptosis. In colorectal tumourigenesis, cells develop mechanisms to evade control signals and are able to survive despite the loss of cellcell contacts. Overexpression of adhesion molecules and an abnormal enhancement of growth factors may be an indicator of colon […]

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