Posts Tagged ‘Cytokines

The Clinical Relevance of Circulating Tumor Necrosis Factor-a in Acute Decompensated Chronic Heart Failure Without Cachexia (Discussion)The findings of this investigation allow us to make two important clinical observations. First, as in other reports, our results allude to […]

The Clinical Relevance of Circulating Tumor Necrosis Factor-a in Acute Decompensated Chronic Heart Failure Without Cachexia (Results)TNFa in CHF Patients and Control Subjects

The mean concentration of TNFa in the normal control subjects was 0.89±0.40 pg/mL (range, 0.5 […]

The Clinical Relevance of Circulating Tumor Necrosis Factor-a in Acute Decompensated Chronic Heart Failure Without Cachexia (Materials and Methods)Study Population

The study population consisted of 29 noncachectic patients (20 men and 9 women; age range, 27 […]

The Clinical Relevance of Circulating Tumor Necrosis Factor-a in Acute Decompensated Chronic Heart Failure Without Cachexia (Introduction)Study objective: To evaluate the clinical relevance of circulating tumor necrosis factor-a (TNFa) in subjects with advanced acutely decompensated congestive heart failure […]

A study by Dong et al has provided further evidence that attenuation of apoptosis may facilitate tumour progression in colon cells. Dong et al examined the role of cytosolic phospholipase A2 (cPLA2) in TNF-a-induced apop-tosis of cultured mouse colonocytes. The specific cPLA-2 inhibitor, AACOCF-3 (arachidonoyl trifluoromethyl ketone), was able to protect colonocytes from TNF-a-induced apoptosis in vitro. The study supports the idea that down-regulation of cPLA2 may attenuate TNF-a mediated apoptosis […]

Apoptosis

Apoptosis is an important regulatory mechanism by which unwanted cells are eliminated in tumourigenesis. Apoptosis is initiated by binding of death receptors such as Fas, TNF-R and TRAIL-R to their ligands. Binding of the receptors results in transmission of apoptotic signals and the activation of enzymatic caspase complexes . IFNs function in […]

Normal colonic epithelial cells are dependent on cell-cell adhesion and survival factors for the inhibition of apoptosis. In colorectal tumourigenesis , cells develop mechanisms to evade control signals and are able to survive despite the loss of cellcell contacts. Overexpression of adhesion molecules and an abnormal enhancement of growth factors may be an indicator of colon tumourigenesis. In a recent study, chronic trinitrobenzene sulfonic acid-induced inflammation of the colon coincided with […]

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