Alcohol consumption has been described as an independent risk factor for COPD-related mortality. Based on this prior research and because of the biological plausibility that heavy alcohol consumption may increase risk of exacerbation either through immune suppression or risk of aspiration, we hypothesized that moderate-to-heavy alcohol consumption when compared to light drinking would be associated with an increased risk for COPD exacerbations in a large, predominantly male cohort of veterans. […]
Treatment of reversible disease of the airways with bronchodilator drugs is generally advocated because of subjective and objective improvement in the obstruction of the airways. A more difficult question arises in the patient with chronic obstructive pulmonary disease (COPD) without evidence of reversible disease of the airways. Various methods of selection of such patients with COPD for treatment with bronchodilator […]
In: COPD17 Oct 2014
However, similar changes in skeletal muscle have been found with aging, disuse and malnutrition and may not be peculiar to patients with COPD. Whatever, the determinants of RM endurance are more complex than the determinants of RM strength.
For the respiratory muscles, four factors could reduce the endurance time: low basal energy stores, low rate of energy supply, reduced efficiency, and an increased external power of breathing.
In: COPD16 Oct 2014
In the endurance test of Nickerson and Keens, mean SIP/MIP percent was 68 ±3 percent. Our normal elderly subjects had a Ppk/MIP of 79 ±19 percent which was similar to the SIP max/MIP of 77 ± […]
In: COPD15 Oct 2014
The MIP increased on subsequent visits in the normal elderly subjects, primarily from visit 1 to visit 2. Since the tests were spaced one week apart and only took 30 min to complete, there should not have been a training effect. Therefore, the increase in MIP suggests a learning effect. This was seen only in the normal subjects who had no experience with any lung function testing. Although the COPD […]
In: COPD14 Oct 2014
This study showed that measures of inspiratory muscle strength and endurance (as measured by the 2-min incremental loading test) were significantly less in naive COPD patients than in the normal elderly subjects matched for age, height, […]
In: COPD13 Oct 2014
There was no difference between the normal elderly subjects and COPD patients in age, sex, height or weight (Table 1). The COPD patients had severe airflow limitation and markedly reduced MW (Table 1). The FEVi, FVC and MW were not different in either group from visit 1 to visit 3.
The MIP was less in COPD patients than normal subjects (p<0.05, Fig 2) at each visit while MEP was […]
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