The application of capsaicin to the rat TMJ region resulted in an inflammatory reaction illustrated by the expansion of the periarticular tissue and plasma extravasation as demonstrated by Evan’s blue dye staining in this area of interest. Since capsaicin binds to VR1 receptors located on primary sensory afferents innervating the rat TMJ region to produce [...]

Among the 64 rats used in this experiment, only data obtained from 48 rats were deemed suitable for analysis. Twelve rats either responded to the injection of saline and the resultant increased EMG activity did not return to baseline levels prior to the injection of capsaicin/ve-hicle, or the application of the preload agent failed to [...]

The University of Toronto Animal Care Committee in accordance with the regulations of the Ontario Animal Research Act (Canada) approved the following protocol. Sixty-four male Sprague-Dawley rats weighing between 225 and 400 g each were prepared for the continuous measurement of one-dimensional tissue expansion, as previously described by Fiorentino et al and Wong et al, [...]

The purpose of this study was to evaluate the effect of local anesthetic blockade of afferent innervation on the development of capsaicin-induced edema in the rat temporomandibular joint (TMJ) region and on reflex jaw muscle activity. Under halo-thane anesthesia, 64 male Sprague-Dawley rats were prepared for monitoring of edema development by lateral movement of a [...]