In summary, mediastinal germ cell tumors, while numerically rare, are among the most common tumors in the anterior mediastinum. This tumor should be considered strongly in the differential diagnosis of anterior mediastinal masses. Benign teratomas are common in this site and complete surgical resection results in cure of nearly all patients. Malignant mediastinal seminomas are […]
The median interval of six months between the two diagnoses in these patients contrasts sharply to the 25 to 60 month interval commonly seen in typical therapy-related hematologic malignancies. In addition, there was no identifiable prodrome of pancytopenia or characteristic cytogenetic abnormalities as is usually seen with therapy-related leukemias and myelodysplastic disorders. Reviews at Indiana […]
In all cases, the mediastinal primary was a nonseminomatous variant. The hematologic malignancy was characterized as acute megakaryocytic leukemia in six patients, mixed lineage acute leukemia (erythroid plus megakaryocytic) in one patient, acute monocytic leukemia in one patient, acute myelomon-ocytic leukemia in one patient, acute undifferentiated leukemia in one patient, myelodysplastic syndrome in two patients, […]
In a review of germ cell tumor specimens at Indiana University from 1974 to 1982, Ulbright and colleagues found 269 cases of teratoma-containing material including 32 mediastinal primaries. Among this group of patients, three cases were identified that demonstrated malignant nongerm cell elements. Expanding experience suggests that a number of histologic variants are encountered including […]
Biologic Associations of Mediastinal Germ Cell Tumors Klinefelter Syndrome: In recent years, there has been an increasing awareness of unique associations of mediastinal nonseminomatous germ cell tumors with a variety of clinical conditions such as nongerm cell malignancies and certain karyotypic abnormalities. The first of these clinical/biologic associations to be recognized was the association of […]
These results suggested that poorly differentiated carcinomas of unknown primary site are responsive to chemotherapy and even chemotherapy curable. A subset of this group of patients probably represent histologically (and serologically) atypical germ cell tumors. As such, patients with metastatic poorly differentiated carcinoma should be investigated for a primary site. Serum HCG and AFP should […]
Light microscopy revealed poorly differentiated carcinoma in 48 patients (68 percent), poorly differentiated adenocarcinoma in 18 patients (25 percent) and poorly differentiated large cell carcinoma in five patients (seven percent). Electronmicroscopy resulted in change in the histologic diagnosis in 17 of 33 patients with poorly differentiated carcinoma undergoing this procedure with neuroendocrine tumors being the […]
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