In: Asthma9 Oct 2014
Both atenolol and celiprolol were modestly effective antihypertensive agents and approximately half of the patients achieved the goal diastolic blood pressure with either agent. The optimal antihypertensive dose for each of these […]
In: Asthma8 Oct 2014
Acute Single-Dose Drug Challenge
Following the single-dose challenge with atenolol, the FEVx, FVC and PEF fell progressively during 3 h, and were significantly lower at the end of the 3 h (p<0.01), but improved significantly (p<0.05) to prechallenge levels after treatment with salbutamol inhaler (Fig 2). After celiprolol therapy, the FEVj, FVC and PEF remained unchanged, yet responsiveness to salbutamol was retained. No deterioration in spiro-metric parameters was seen […]
In: Asthma7 Oct 2014
These data served as an indication of the chronic day-to-day control of asthma throughout the 12-week study.
Adverse effects volunteered by […]
In: Asthma6 Oct 2014
After a single-blind two-week placebo run-in period, the patients were randomly given in a double-blind manner either 100 mg atenolol or 400 mg celiprolol daily for four weeks. Thereafter, all patients completed a two-week placebo crossover period and then received the alternative beta-blocker daily for a further four-week period (Fig 1).
Patients were seen every two weeks. At each visit, blood pressure with the patient in […]
In: Asthma5 Oct 2014
The danger of using beta-adrenergic blockers and particularly those without cardiac selectivity in asthmatic patients has been known for more than 20 years. Even relatively cardioselective agents (including atenolol) have been shown to produce […]
In: Asthma14 Jun 2014
The study groups were relatively small in most of the reports. Only four studies had more than 20 subjects who completed the protocol (Table 1). This raises concerns that a beta error may have masked a beneficial effect of medical antireflux therapy. The average change in FEV1 in these studies was less than 5%, with an SD of approxi mately 30%. The required sample size, with an alpha of 0.05 […]
In: Asthma12 Jun 2014
These studies may have been too short to allow the complete benefit from antireflux therapy to become apparent. One surgical series presented 5-year follow-up data indicating an improvement in lung function. One half of the patients in […]
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