Posts Tagged ‘asthma

Both atenolol and celiprolol were modestly effective antihypertensive agents and approximately half of the patients achieved the goal diastolic blood pressure with either agent. The optimal antihypertensive dose for each of these patients might not have been given, although the doses chosen are of established antihypertensive potency. Neither atenolol nor celiprolol affected daily asthma control […]

Acute Single-Dose Drug Challenge Following the single-dose challenge with atenolol, the FEVx, FVC and PEF fell progressively during 3 h, and were significantly lower at the end of the 3 h (p<0.01), but improved significantly (p<0.05) to prechallenge levels after treatment with salbutamol inhaler (Fig 2). After celiprolol therapy, the FEVj, FVC and PEF remained […]

These data served as an indication of the chronic day-to-day control of asthma throughout the 12-week study. Adverse effects volunteered by patients were recorded. Study medications were returned at each visit and checked to confirm compliance. Statistical Procedures Data were analyzed using paired f-tests with the Bonferroni correction for multiple comparisons. Since one of the […]

Trial Procedure After a single-blind two-week placebo run-in period, the patients were randomly given in a double-blind manner either 100 mg atenolol or 400 mg celiprolol daily for four weeks. Thereafter, all patients completed a two-week placebo crossover period and then received the alternative beta-blocker daily for a further four-week period (Fig 1). Patients were […]

The danger of using beta-adrenergic blockers and particularly those without cardiac selectivity in asthmatic patients has been known for more than 20 years. Even relatively cardioselective agents (including atenolol) have been shown to produce significant bronchoconstriction, and for this reason are strictly contraindicated in asthma. One possible way of overcoming the adverse effects of beta-blockade […]

The study groups were relatively small in most of the reports. Only four studies had more than 20 subjects who completed the protocol (Table 1). This raises concerns that a beta error may have masked a beneficial effect of medical antireflux therapy. The average change in FEV1 in these studies was less than 5%, with […]

These studies may have been too short to allow the complete benefit from antireflux therapy to become apparent. One surgical series presented 5-year follow-up data indicating an improvement in lung function. One half of the patients in another study were free of respiratory symptoms 77 months after antireflux surgery. Perhaps improvement in pulmonary function would […]

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