In: Anesthesia
22 Feb 2010Smoking is an addictive process. The sensation of drawing smoke into the mouth and the effect of nicotine provides smokers with satisfaction. Acute withdrawal may result in increased anxiety, sleep disturbances, and irritability.
In: Anesthesia
21 Feb 2010In moderate or heavy smokers, the forced expiratory volume-/second (FEV-l) is reduced following spinal anesthesia above T10. Also, the forced midexpiratory flow and the forced expiratory flow are markedly reduced. Thus, for prevention of accumulation of secretions in small airways, it is advised that patients be in structed to frequently take deep breaths and cough [...]
In: Anesthesia
20 Feb 2010Smoking increases the production of Hb, red blood cells, white blood cells, and platelets and increases plate let reactivity. There is also an increase in fibrinogen. These result in an increase in the hematocrit and the blood viscosity, leading to an increased thrombotic tendency. The result is an increased incidence of arterial thromboembolic disease in [...]
In: Anesthesia
19 Feb 2010Despite the warnings of health hazards of cigarette smoking, still one third of the population in industrial countries smoke. Cigarette smoke contains over 4000 substances, some of which are pharmacologically active, some antigenic, some cytotoxic, some mutagenic, and some others carcinogenic. It consists of a gaseous phase and a particulate phase. Eighty to 90% of [...]
In: Anesthesia
15 Jan 2010The most common untoward effect elicited by propofol is pain on injection. This is observed in 31% of patients when using the dorsum of the hand and 8% when accessing the vein in the anticubital fossa. Means of alleviating this discomfort include injecting intravenously 10 mg of 1% lidocaine 10 seconds before propofol delivery or [...]
In: Anesthesia
14 Jan 2010The effective induction dose of 1% propofol in healthy nonpremedicated adults is 2-2.5 mgAg IV. For individuals over 60, 1.5 mgAg is generally adequate. This induction dose is also reduced by premedication with benzodiazepines or opioids. In children, the dose requirement is increased by 1.5 times due to the shorter elimination half-life in the pediatric [...]
In: Anesthesia
13 Jan 2010The most clinically significant pharmacodynamic properties of propofol deal with the neurologic, cardiovascular, and respiratory systems. Propofol produces rapid hypnosis and has synergistic activity when administered concurrently with barbiturates, benzodiazepines, and opioids. Hypnosis is induced by the action of propofol on the alpha subunit of the 7-aminobutyric acid (GABA) receptor in the brain. Anticonvulsant activity [...]
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