In: Drug23 May 2010
Erectile dysfunction (ED) refers to the inability of a man to achieve or maintain an erection that is sufficient for his sexual needs or the needs of his partner. ED affects 150 million men worldwide, including an estimated 15 to 30 million men in the U.S. The incidence of the disorder increases with age. Chronic ED affects approximately 5% of men in their 40s and 15% to 25% of men by the age of 65. As many as 50% of men between ages 40 and 70 are affected by transient ED and inadequate erections.
The incidence of ED is projected to increase sharply over the next 25 years. It may also be a biobehavioral marker for, depression, and/or cardiovascular disorders.
Advances in protein chemistry and molecular biology, along with an increased understanding of the mechanisms involved in a penile erection, have sparked the development of medicinal approaches to the treatment of ED. The three orally active medications available for patients with ED are (Viagra canadian, Pfizer), (Levitra drug, Bayer/GlaxoSmithKline), and tadalafil (Cialis canadian, Eli Lilly). Tadalafil medication is the latest of the three to be approved by the Food and Drug Administration (FDA). This medication is a highly selective, potent, reversible inhibitor of phosphodiesterase type 5 (PDE5).
In the treatment of any disorder for which more than one drug in the same or a similar class is available, the patient’s preference is an important issue for physicians to consider; this is true in the case of ED because it is a subjective complaint. Differs from the other two products in that it stays in the body for a longer time, which is an advantage for men with ED.
For a penile erection to occur, a sequence of events must take place. ED can result if the order of any of these events is disrupted. These events include the transmission of nerve impulses in the brain, spinal column, and the area around the penis as well as responses in the muscles, fibrous tissues, veins, and arteries in and near the corpus cavernosum. Nerve damage and a reduced blood flow to the penis are the most common physical causes of disruption. Underlying conditions associated with ED include the fol-lowing:
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