Real and Pseudo Late Asthmatic Reactions after Submaximai Exercise Challenge in Patients with Bronchial Asthma (4)

In: Asthma

25 Jan 2013

PEFR was measured only once. In 81 patients, the PEFR values on the control day and on the morning of the next day were not below 65 percent of predicted value. These patients were exercised. Their characteristics are shown in Table 1. The patients started EC exactly at the same time as the first PEFR measurement on the control day. Room temperature was 18° to 23°C and relative humidity of ambient air was 20 to 40 percent. The EC consisted of 8 minutes of cycling on a bicycle ergometer (Erich Jager, Wurzburg, Germany). Workload was gradually increased until 80 percent of the predicted maximal heart rate was reached and continued for at least 4 minutes at this level. During EC, heart rate and ECC were monitored (Sirecust 341, Siemens. Germany). The subjects wore a nose clip. Prior to EC, baseline PEFR was measured twice with an interval of five minutes. After EC, PEFR was measured at 1,3, 5, 7, 10, 15, and 30 minutes and 1 hour and hourly for 12 hours as on the control day.
The protocol was approved by the Ethical Committee of the Centre and all patients gave written informed consent. ventolin inhaler
Study 1
The coefficient of variation of the PEFR was calculated over the 13-hour measurement period on both study days in the 21 asthmatic patients. In each patient, the ten PEFR values in the first 30 minutes of both study days were compared by analysis of variance in patients to determine day-to-day variability in baseline value. From this, the within-subject difference in baseline value on the control and exercise days allowed in study 2 was defined. Variability and reproducibility of the PEFR on the entire study days in the 21 patients were analyzed by repeated measurements analysis of variance.

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