Real and Pseudo Late Asthmatic Reactions after Submaximai Exercise Challenge in Patients with Bronchial Asthma (3)

In: Asthma

24 Jan 2013

Real and Pseudo Late Asthmatic Reactions after Submaximai Exercise Challenge in Patients with Bronchial Asthma (3)Study 1
This study was done in 21 asthmatic patients who were treated in the Dutch Asthma Centre Davos and who fulfilled the following inclusion criteria: (a) age 12 to 65 years; (b) clinical diagnosis of bronchial asthma, according to the criteria of the American Thoracic Society; (c) baseline PEFR (first measurement in the morning on each of both study days) ^65 percent of predicted; and (d) PC20 to histamine (the concentration of histamine that resulted in a 20 percent decline in FEV, of baseline was measured) ^8 mg/ml. Patient characteristics are given in Table 1.
Treatment with oral bronchodilators was stopped 48 hours before the study day; treatment with cromolyn sodium was stopped 24 hours before the study day; and treatment with inhaled bronchodilators was stopped ^8 hours before the study day. Treatment with oral and/or inhaled corticosteroids was continued.
The PEFR was measured with a mini-Wright peak flow meter (Airmed) ten times in the first 30 minutes in the morning and hourly thereafter for 13 hours. The peak flow meters were cleaned after each measurement to prevent excessive humidity. The best of three consecutive PEFR values was recorded. buy asthma inhalers
Study 2
One hundred ten patients who were treated in the Dutch Asthma Centre Davos and fulfilled the same inclusion criteria as in study 1 were selected. The PEFR was first measured on a control day as in study 1 with the exception that in the first 30 minutes in the morning,

Table 1—Characteristics of Patients in Study 1 and 2

Study 1 Study 2
No. of patients 21 81
Age, yr, mean ± SD 25.8 ± 14.1 25.5± 11.7
FVC, % predicted, mean ± SD 98.9 ± 12.4 103.0 ±18.3
FEV,, % predicted, mean ± SD 81.0±21.3 89.0 ±22.9
Histamine PC20, mg/ml, mean ± SD 1.5±2.6 1.0± 1.7
Corticosteroids: none/oral/inhaled/ 1/5/11/4 9/7/45/26
both (No. of patients)

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