Real and Pseudo Late Asthmatic Reactions after Submaximai Exercise Challenge in Patients with Bronchial Asthma (2)

In: Asthma

23 Jan 2013

In the present study, we investigated the prevalence and pattern of the fall in PEFR after EC in patients with asthma studied by Speelberg et al. The effects of withdrawal of treatment and EC were separated by monitoring PEFR after medication withdrawal only and after medication withdrawal followed by EC. Spontaneous variability of PEFR in the population is determined and graphs are drawn of those patients demonstrating a late fall in PEFR after EC of more than 20 percent.
Patients and Methods
The study consisted of two parts. In study 1, PEFR was measured on two separate study days after withdrawal of medication without exercise. This study was performed to determine spontaneous PEFR variability on two separate days in the population studied. In study 2, PEFR was measured after the same medication withdrawal regimen as in study 1 on a day without exercise (control day) and on a day on which a submaximal EC was performed (exercise day). This study was performed to determine the prevalence of a late fall in PEFR ^20 percent after EC in the patients studied and to visualize this late fall in PEFR in graphs, both on control and on exercise day.
In the study, an early asthmatic reaction (EAR) was defined as a fall in PEFR from baseline of at least 20 percent one to 60 minutes after EC. A LAR was defined as a fall in PEFR from baseline of at least 20 percent 4 to 13 hours after EC. A true LAR was defined as a fall in PEFR from baseline of at least 20 percent on three successive occasions 4 to 13 hours after EC on the exercise day, without a similar fall in PEFR from baseline at similar time points on the control day. A pseudo LAR was defined as a fall in PEFR from baseline of at least 20 percent 4 to 13 hours after EC on the exercise day, accompanied by a similar fall in PEFR from baseline at similar time points on a control day.


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