Progesterone-Growth Factor Interactions in Uterine Stromal Cells: A NEW MODEL FOR STUDYING PROGESTERONE(5)

In: Progesterone

10 Feb 2013

After DNA replication, stromal cells differentiate into decidual cells with characteristic changes in morphology. Decidual cells express alkaline phosphatase and placental lactogens and are joined by gap junctions. In the mouse uterus, a population of periluminal stromal cells replicate their DNA but do not undergo mitosis. Decidual nuclei are polyploid, as the chromosomes fail to separate at metaphase and increased ploidy from 4 to 32 n is reported. While endomitosis is not common in mammalian cells, it has been reported in trophoblast cells and in bone marrow megakaryocytes during terminal differentiation. In the latter case, inactivation of mitosis-promoting factor uncouples DNA replication from mitosis. buy asthma inhalers
Results from cell cycle analysis of uterine stromal cells are expected to contribute new insight into the role of progesterone and its receptor in the control of cell cycle progression and stromal cell differentiation. Progesterone is the only hormone required for the establishment of pregnancy in all mammals, yet its mechanism of action in endometrial cells is poorly understood from a mechanistic viewpoint. The results emerging from cell cycle analysis can be used as a paradigm to define the molecular targets for progesterone-dependent proliferation. Progress in this area is essential to identify the targets for progesterone-dependent cell cycle progression and to lay the foundation for future studies to systematically analyze endocrine control of cellular differentiation and apoptosis.


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