In: Bleomycin5 Apr 2013
Bleomycin is degraded by bleomycin hydrolase, an enzyme which cleaves carboxyamide groups.- It is postulated that the relative lack of this enzyme in the human lung may contribute to an increased tissue level of the drug in the lung. Studies in animals have confirmed that bleomycin is concentrated in the lungs and in the skin. This concentration of drug, combined with the high oxygen content in the lung, may also contribute to the susceptibility of the lung to damage by bleomycin. In contrast to the findings in animals, a review by Comis points out that there have been no studies done in humans to assess either bleomycin hydrolase activity or a preferential distribution of the drug to the lungs. Cheap Diskus Advair
When bleomycin is administered intravenously to humans, the elimination half-life is 2 to 4 h; 50 to 70 percent of the drug is recovered in the urine within 24 hours.- Because such a large percentage of the drug is excreted in the urine, associated renal insufficiency could result in significantly increased levels of bleomycin in the lung and enhance its toxicity. A single dose results in maximal drug levels in the kidney and lung at 5 h. Five days after treatment, significant levels are present only in the lungs and the skin of experimental animals.
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