In: Bleomycin18 Apr 2013
One patient developed pneumonia, which was treated with antibiotics, and another had postoperative atelectasis. These investigators concluded that a higher FIo2 than that reported in the series of Goldiner et al was not detrimental in patients with testicular cancer who had received bleomycin. ampicillin antibiotic
In a recent report of the work by Blom-Muilwijk et al in the Yearbook of Anesthesiareviewers cited the studies by LaMantia et al and by Douglas and Coppin as supporting evidence that high levels of FIo2 administered to bleomycin-treated patients during general anesthesia may be safer than once thought. It should be pointed out that the numbers of patients in these two studies were quite low. In studies with larger populations, the incidence of nonlethal fibrosis in all patients receiving bleomycin was 11 to 30 percent, and the mortality in patients with fibrosis was 2 to 10 percent. Because the study by LaMantia et al was concerned with a subgroup of these larger populations (bleomycin-treated patients who were anesthetized), the findings of these larger studies cannot be directly extrapolated to the work of LaMantia et al. The numbers of patients in the studies by Goldiner et al by LaMantia et al, and by Douglas and Coppin were all quite small and are therefore potentially limited by statistical errors. Larger studies are needed to definitely conclude that high levels of FIo2 are either safe or unsafe.
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