In: Bleomycin15 Apr 2013
A recent study in rats by Blom-Muilwijk et al attempted to simulate both the dose of bleomycin commonly used to treat human malignancies and the FIo2 (50 percent) and duration (4 h) of hyperoxia used during general anesthesia. The only histologic change one week after treatment was an increase in the number of alveolar macrophages in the bleomycin-treated rats compared to the saline controls. The animals treated with bleomycin and hyperoxia had significantly more intra-alveolar macrophages than those treated with bleomycin alone. birth control yasmin
This study implied that the hyperoxic exposure normally encountered in general anesthesia may not significantly potentiate bleomycin-induced toxicity; however, the histologic changes were assessed only at one week after treatment. Although fibrotic changes have been reported one week after treatment in rats, this may not be sufficient time for significant changes to develop. There are known differences in the extent of bleomycin toxicity between species and even in different strains of the same species. The lack of additional toxicity in rats with the levels of hyperoxia used in the study by Blom-Muilwijk et al is encouraging, but the results cannot be readily extrapolated to humans.
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