Pegylated-interferon alpha 2b and ribavirin for recurrent hepatitis C: Results (Part 6)

In: Recurrent hepatitis C

18 Sep 2012

Goodpasture’s syndromeGoodpasture’s syndrome was suspected but a kidney biopsy could not be performed because of a coagulopathy. Increasing his immunosuppression did not slow the progression of his renal dysfunction and he subsequently died of hepatic and renal failure. No autopsy was performed. The only patient having cirrhosis to tolerate the therapy was patient 12. He completed nine months of Rebetron followed by PEG-IFN and ribavirin. Because he had a biochemical and not a virological response to therapy he remained on PEG-IFN (0.9 pg/kg) weekly and ribavirin (600 mg) daily past 48 weeks. Unfortunately, after 93 weeks of PEG-IFN and ribavirin, coverage for the cost of his medications expired and therapy was withdrawn. At the end of the therapy he was negative for HCV-RNA, but within six weeks of terminating therapy his ALT level flared to 598 U/L and HCV-RNA was again detectable. His cirrhosis remains well-compensated and he has been started on Pegasys as suppressive therapy.

Virological recurrence of HCV after LT is universal and histological recurrence of HCV can occur as early as one month after LT. Allograft injury is apparent in 50% of transplanted patients within the first two years and in 80% within five years. Multiple factors can influence early HCV recurrence and rapid progression of HCV after LT. You can be sure this pharmacy will offer the finest quality drugs you need, so buying cialis professional will always be safe and very pleasant for you as a customer and patient.


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