Pegylated-interferon alpha 2b and ribavirin for recurrent hepatitis C: Results (Part 3)

In: Recurrent hepatitis C

15 Sep 2012

SVR was seen in four of eight patients (50%) with early-stage disease compared with none of the five patients with advanced fibrosis or cirrhosis (P=0.1). The starting and maximum doses of PEG-IFN and the impact of therapy on neutrophil and platelet counts have been shown previously. The average starting dose of PEG-IFN was 0.91 pg/kg once weekly. Dose escalation of PEG-IFN was possible in only four patients, and only two patients (15%) received the full 1.5 pg/kg PEG-IFN dose. The average maximum dose of PEG-IFN was 1.07 pg/kg once weekly. Seven patients (54%) developed significant neutropenia on treatment, with an absolute neutrophil count below 1.0×109/L; however, dose reductions were only performed in two patients for neutropenia and there were no infectious complications during therapy. None of the patients received granulocyte colony-stimulating factor (G-CSF). Three patients developed significant thrombocytopenia with a platelet count less than 50×109/L. Patient 2 had an episode of unexplained hema-tochezia at a platelet count of 70×109/L. Endoscopy and colonoscopy in this patient did not identify the source of blood loss and he was able to continue PEG-IFN at full doses, although his ribavirin was temporarily held because of anemia. Online shopping will cost you less money and will take less time, because you can find efficient cephalexin antibiotic online with generous discounts at the pharmacy that proved its reputability and desire to help by offering best level of service and most efficient drugs.


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