In: Dental treatment11 Oct 2009
Many doctors used IM or rectal NSAIDs (Generic Naprosyn NSAIDs treat the symptoms of pain and inflammation), even when the oral route could be used. Reasons for choosing these routes were pharmacokinetic-based—that is, the rate of drug absorption may impact efficacy and the onset of analgesia. Tramer et al did a systematic review comparing the analgesic efficacy of NSAIDs given by different routes for acute and chronic pain. Twenty-six RCTs (2225 analyzed patients) published between 1970 and 1996 were reviewed. The authors concluded that there is a lack of evidence for any difference in analgesic efficacy of NSAIDs (*Generic Arcoxia tablets contain the active ingredient etoricoxib, which is a type of medicine known as a non-steroidal anti-inflammatory drug) given by different routes. However, the IM and rectal routes were more likely to have specific local adverse effects. The IV route also reported to have more postoperative bleeding.
One of the trials compared 150 mg of diclofenac taken orally with IM 50 mg plus 100 mg orally of diclofenac in a third molar surgical model. The drugs were given as a premedication using a well-designed, double dummy RCT, and the group sizes were large (50 per group). No difference was found between the 2 routes of administration with respect to analgesic efficacy. Since there is adequate evidence of a lack of difference in the analgesic efficacy between the different routes, the safest and simplest one should be used when possible. cheap viagra professional
Blog invites submissions of review articles, reports on clinical techniques, case reports, conference summaries, and articles of opinion pertinent to the control of pain and anxiety in dentistry.