In: Dental treatment15 Oct 2009
There are different pain models and varying methods for studying analgesic agents. The dental pain impaction model has been chosen in this review, and the analgesic studies were single-dose studies or multidose studies. It should be noted that the majority of the RCTs reviewed in this article are single-dose analgesic studies. Single-dose studies are good and appropriate because they are excellent predictors of analgesic efficacy and can be used to determine the optimal analgesic dosage and time-effect of that drug as well as its relative efficacy to known standards. However, single-dose studies that on the very first dose does not have any advantage over the standard treatments.
Recently, there has been a growing recognition of the importance of augmenting the traditional approach of single-dose analgesic studies with multidose efficacy trials. This multidose model more closely approximates the “real life” clinical setting. Patients with pathologic pain typically require more than 1 dose of medication to alleviate their pain. In addition, information concerning the optimal dosing frequency and the side effect profile can best be obtained from multidose studies. Dental postoperative pain is a good model for both single-dose and short-term multidose study. Pain arising from this surgical procedure usually persists for 3-4 days. However, the usefulness of this model in a short-term multidose study is underscored, as there are very few multidose studies for this model to date. More multidose analgesic studies in this model should be done in the future to better delineate the safety profile of analgesics.
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Blog invites submissions of review articles, reports on clinical techniques, case reports, conference summaries, and articles of opinion pertinent to the control of pain and anxiety in dentistry.