Nonalcoholic fatty liver disease: RESULTS (Part 1)

In: Nonalcoholic fatty liver disease

8 Jul 2012

The age of the 49 patients selected from the original 202 patients was 46.4±13 years (mean ± SE). As Table 2 shows, the patients were distributed across all age groups from 20 to more than 60 years, reflecting the heterogeneous nature of patients who are investigated for NAFLD. Table 2 also shows that the sex of the selected patients was equally divided between male and female. Finally, 63.2% of the 49 selected patients were seen at clinics in community-based hospitals compared with 36.7% seen at the regional liver transplant centre.

TABLE 2 Characteristics of the 49 patients identified with nonalcoholic fatty liver disease

Variable Value
Age (years)
Mean ± SE 46.4±13.2
<40 (%) 17 (34.7)
41-50 (%) 9 (19.1)
51-60(%) 15 (30.6)
>61 (%) 8 (16.3)
Male sex (%) 25 (51.0)
Hospital distribution (%)
Royal Alexandra Hospital 24 (48.9)
Grey Nuns Hospital 7 (14.3)
University of Alberta Hospital 18 (36.7)

Table 3 summarizes the liver biopsy findings. All patients had hepatic steatosis. None had microvesicular steatosis. The degree of steatosis was concordant with the extent of inflammation and fibrosis in 63% of cases (that is, patients with mild steatosis had no or minimal fibrosis and those with severe steatosis had significant fibrosis). Ballooning hepatocytes were seen in 79.6% of the patients, of whom 92% had evidence of fibrosis in zone 3, qualifying them for a classification of NASH. Of patients with NASH, 16.7% had cirrhosis. The presence of Mallory’s hyaline bodies was reported in 36.7% of the patients and was associated with advanced fibrosis and inflammation. Finally, iron staining was assessed in 47 of the 49 patients and was positive in 16. There was no correlation between the presence or degree of iron staining and the stage of fibrosis or inflammation. You will love this opportunity to spend less money whenever you need to order antibiotics online *best price only here for your symptoms to be under control, so you definitely should check out the pharmacy that will be happy to help you no matter which drug you need and how often.

TABLE 3 Histological findings of patients identified with nonalcoholic fatty liver disease

Finding Number of patients (%)
Macrovesicular steatosis
Mild 23 (46.9)
Moderate 18 (36.7)
Severe 8 (16.3)
Evidence of zone 3 ballooning
Absent 10 (20.4)
Present 39 (79.6)
Necroinflammatory grade
1 30 (61.2)
2 17 (34.7)
3 2 (4.1)
Mallory bodies
Absent 31 (63.3)
Present 18 (36.7)
Fibrosis stage
0 12 (24.5)
1 14 (28.6)
2 9 (18.4)
3 9 (18.4)
4 5 (10.2)
Iron staining (n=47)
None 31 (66.0)
Positive 16 (34.0)

 

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