Nonalcoholic fatty liver disease: METHODS (Part 1)

In: Nonalcoholic fatty liver disease

5 Jul 2012


The search terms ‘macrovesicular steatosis’, ‘steatohepatitis’, ‘fatty change’ and ‘fatty hepatitis’ were used to locate liver biopsy reports from the computerized pathology registry of the regional health authority. The search spanned the time period between January 1996, when the computerized pathology registry was first set up, and April 2000. Ethical approval of the study was obtained from the regional health care authority. Two hundred and two patients were identified from the search and all their charts were reviewed.

The inclusion criterion was patients who had undergone biopsies exclusively as part of an assessment for elevated liver enzymes in the absence of significant alcohol history and with negative investigations for other causes of liver disease. All patients included in the study were screened for viral hepatitis (hepatitis B surface antigen, hepatitis C virus antibody), nuclear antibody, mitochondrial antibody, smooth muscle antibody, alpha 1 antitrypsin, copper and ceruloplas-min. Hemochromatosis was excluded by biopsy, by normal ferritin concentrations, and in patients with increased serum ferritin by liver biopsy and molecular genetic analysis for C282Y and H63D genes. Table 1 outlines the reasons for excluding 153 patients from the original list. buy birth control online –

TABLE 1 Reasons for exclusion from the study in a group of 202 patients with steatosis identified in a liver biopsy

Reason for exclusion Number of patients
History of ethanol intake 24
Remote history of ethanol intake 10
Presence of viral hepatitis 28
Investigation for hepatic mass 22
Use of known hepatotoxic drugs 10
Cadaveric donor liver 9
Prior liver transplantation 5
Hemachromatosis 2
Presence of obstructive liver disease 12
Age less than 18 years 3
Incomplete records 25


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