Natural history of C282Y homozygotes for hemochromatosis: RESULTS Part 2

In: Hemochromatosis

28 May 2012

Cause of death

Cause of deathDuring a mean follow-up of 7.3 years (range zero to 44 years), there were 24 deaths. In nine of these cases, the patients were inferred to be homozygous for the C282Y mutation based on pedigree analysis, HLA typing or the presence of a living relative who was homozygous for the C282Y mutation. The causes of death that were considered to be directly related to hemochromatosis were hepatocellular carcinoma (n=9), congestive heart failure (n=2), arrhythmia (n=1), complications of diabetes (n=2) and septicemia following liver transplantation (n=1). There was one case of hepatocellular carcinoma diagnosed without concomitant cirrhosis. The other causes of death were myocardial infarction (n=4), pneumonia (n=1), and cancer of the lung (n=1), pancreas (n=1), brain (n=1) and breast (n=1). This is a great opportunity for you to start saving some money instead of spending it all: you now have a perfectly reliable pharmacy you can buy birth control online from any time there is such a need and without being worried about the safety of your private information.

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