Clinical Presentation: The symptoms that prompt medical attention in patients with mediastinal germ cell tumors are, in part, dependent upon the histologic subtype. Benign teratomas are frequently discovered on chest roentgenography while the patient is asymptomatic. When symptoms of benign teratoma are present, these are frequently symptoms of local growth of the tumor within the anterior superior mediastinum. Chest pain, dyspnea, and cough occur frequently. Less commonly, patients can develop superior vena cava syndrome, rupture into the tracheobronchial tree, or pneumonia. birth control yasmin
Malignant germ cell tumors of the mediastinum are more apt to be associated with the symptoms or physical findings. In most series, as many as half of the patients with benign teratomas were without clinical symptoms at presentation, whereas 90 to 100 percent of patients with malignant mediastinal germ cell tumors have clinical symptoms. Symptoms are commonly of short duration with chest pain, dyspnea, and cough being the most frequent complaints. Weight loss and fever are the most common systemic symptoms. Occasionally, patients present with symptoms of metastatic disease with lung parenchyma, liver, and bone being the most frequently affected sites.
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