Mediastinal Germ Cell Tumors (5)

In: Mediastinal Germ Cell Tumors

15 Mar 2013

Mediastinal Germ Cell Tumors (5)Of the 107 patients with primary testis tumors, eight were from racial minorities (Hispanic, five; Asian-American, one; African-American, one; American Indian, one). Review of other series of mediastinal germ cell tumors likewise suggests that racial minorities are over-represented relative to the incidence of testicular cancer among these minorities.’ buy flovent inhaler
Histopathology: All histologic variants of gonadal germ cell tumors are found among mediastinal germ cell tumors. The most common germ cell tumor, particularly in children, is benign teratoma. These tumors exhibit a variety of mature tissues from the three germ cell layers. The term “dermoid cyst” is commonly applied due to the frequent expression of the ectodermal component of the teratoma. Skin is found in over 90 percent of the cases along with smooth muscle (70 percent) and respiratory epithelium in 60 percent of cases. Benign teratoma constitutes approximately 70 percent of mediastinal germ cell tumors in childhood and 60 percent in adults. The most common malignant mediastinal germ cell tumor is seminoma which makes up about 40 percent of the malignant subset. Teratoma with embryonal cell carcinoma (teratocarcinoma) appears the next most common subtype with the histologically restricted variants of pure endodermal sinus tumor, choriocarcinoma or embryonal cell carcinoma being much less frequent.

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