Within the subset of germ cell neoplasms, mediastinal germ cell tumors account for only one to three percent of all germinal tumors. However, mediastinal germ cell tumors represent the most common extragonadal primary site and account for 50 to 70 percent of all germ cell tumors in most adult series. Mediastinal germ cell tumors of childhood are seen across all ages and in both males and females. They account for approximately 7 percent of all germ cell tumors in children. buy ventolin inhalers
In adults, women and men have an equal distribution of benign germ cell tumors, but there is a marked male predominance for malignant mediastinal germ cell tumors. Regardless of histologic subtype, in excess of 90 percent of malignant germ cell tumors of the mediastinum occur in men. In children, mediastinal germ cell tumors, both malignant and benign, appear to be equally distributed among male and female patients.
Most mediastinal germ cell tumors in adults occur in the third decade of life. In contrast to gonadal germ cell tumors where seminomatous variants occur a decade later than nonseminomatous variants, primary mediastinal seminoma appears at a relatively young age similar to mediastinal nonseminomatous germ cell tumors. Despite this peak incidence at a young age, advanced age does not exclude the diagnosis of mediastinal germ cell tumors and there have been well documented cases of mediastinal germ cell tumors in patients over 60 years of age.
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