Mediastinal Germ Cell Tumors (20)

In: Mediastinal Germ Cell Tumors

30 Mar 2013

In a review of germ cell tumor specimens at Indiana University from 1974 to 1982, Ulbright and colleagues found 269 cases of teratoma-containing material including 32 mediastinal primaries. Among this group of patients, three cases were identified that demonstrated malignant nongerm cell elements. Expanding experience suggests that a number of histologic variants are encountered including embryonal rhabdomyosarcoma, small cell undifferentiated carcinoma, neuroblastoma or adenocarcinoma. This association of malignant nongerm cell elements with germ cell tumors appears to be much more common in primary mediastinal germ cell tumors than in tumors of gonadal origin. buy cheap antibiotics
Hematologic Malignancies: In 1985, several case reports of the association of mediastinal germ cell tumors and hematologic malignancies suggested a biologic association between these two malignancies. Additional case material and new cytogenetic information has allowed for refinement of this syndrome. At Indiana University between 1976 and 1989, 16 cases of the association of primary mediastinal germ cell tumors and hematologic malignancies were seen. These cases included five patients who developed a hematologic malignancy among the 31 patients receiving initial chemotherapy at Indiana University for primary mediastinal germ cell tumors during this period. Four patients were referred for evaluation after developing the hematologic malignancy and case material from other institutions was reviewed in seven additional cases.

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