Mediastinal Germ Cell Tumors (17)

In: Mediastinal Germ Cell Tumors

27 Mar 2013

Mediastinal Germ Cell Tumors (17)Light microscopy revealed poorly differentiated carcinoma in 48 patients (68 percent), poorly differentiated adenocarcinoma in 18 patients (25 percent) and poorly differentiated large cell carcinoma in five patients (seven percent). Electronmicroscopy resulted in change in the histologic diagnosis in 17 of 33 patients with poorly differentiated carcinoma undergoing this procedure with neuroendocrine tumors being the most frequent change in diagnosis. buy yasmin online
Sixty-eight of the 71 patients received some form of therapy with 62 patients receiving cisplatin-based combination chemotherapy known to be effective in germ cell cancer. In this group, 15 patients (23 percent) had complete responses and 18 patients (29 percent) had partial responses. Eight of the 15 patients have remained continuously free of disease.
The dominant clinical characteristics of the 15 patients achieving complete response were young age (median 39 years), male sex (12 of 15 patients were men), and midline involvement with mediastinal, retroperitoneal, or cervical lymph node involvement. All 15 patients had a light microscopy diagnosis of poorly differentiated carcinoma. Ten of these biopsy specimens were examined by electron microscopy and this examination resulted in a change to neuroendocrine tumor (one), adenocarcinoma (three), and carcinoid (one).


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