Lactate Levels as Predictors of the Relationship between Oxygen Delivery and Consumption in ARDS: Discussion (3)


20 Jan 2013

Our findings are consistent with investigations of patients with systemic sepsis. Many patients with ARDS have sepsis as well. The similarity in patterns of systemic oxygen utilization in sepsis and ARDS may also be attributed to similar systemic pathophysiology in both conditions, pathophysiology that may be a characteristic of severe systemic inflammation. asthma inhalers

Increased levels of vasoactive and biochemically active mediators of inflammation, for example, produce a variety of changes, including alterations in vascular tone, increases in microvascular permeability, intra-vascular coagulation with fibrin microembolization, microvascular platelet and white blood cell aggregation, and interstitial and endothelial edema. If these changes unfavorably affect the distribution of perfusion or increase diffusional distances for oxygen to cells, they will increase the likelihood for anaerobic conditions to develop. The fact that multiple organ failure, bacterial infection, and clinical signs of sepsis frequently characterize patients who die with ARDS suggests the presence of a severe inflammatory insult.

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