Innovative Chemotherapy: Animal Models

In: Chemotherapy

18 Nov 2014

The former results in higher take rates and rapid fatality. Of interest, the intracranial tumors selectively locate in meningeal and ventricular sites. Thus, it represents a useful model of meningeal carcinomatosis. While only a few tumors can be transplanted intraperito-neally, widespread dissemination may result, with frequent involvement of pleural and pericardial spaces. Thus, these inoculation routes may provide useful models for pleural and pericardial involvement. Other occasionally utilized sites include intrathoracic, intrasplenic and intravenous inoculations. The recently described technique of intrabron-chial inoculation offers a unique orthotopic model for studying the biology of peripheral airway tumors. other

While nude mouse xenografts offer useful biologic tools, as well as a method for propagation of human tumor cells, they are impractical as a method for selection of individualized therapy. Part of the reason is the lengthy and highly variable latent period before the appearance of grossly detectable tumor growth, especially after inoculation of fresh tumor material. For these reasons, considerable interest has been generated in the subrenal capsule assay originally described by Bogden. In this assay, tumor tissues are xenografted into the subrenal capsule of either immunosuppressed or immunocompetent mice. Tumor growth is evaluated after a short time, frequently 6 days. Thus, the assay, theoretically, may be used to select individualized therapy. In an extensive study of the assay with non-SCLC (NSCLC) by Tueni et alfl utilizing immunocompetent mice, they found the method to be totally inappropriate. Many of the specimens contained large fod of necrosis or hemorrhage, and grafts that appeared to contain macroscopic tumor failed to contain tumor on microscopic examination. While this method may be suitable to test cell lines, it does not appear to be practical for fresh lung cancer tumor tissues.


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