Influenza in Patients with Human Immunodeficiency Virus Infection: Discussion (Part 1)

In: Influenza

23 Nov 2012

We describe six patients with HIV infection in whom influenza virus was isolated from induced sputum or BAL specimens at SFGH between December 1988 and March 1989. The patients comprising this report were sufficiently ill to warrant evaluation for P carinii pneumonia. Therefore, we believe that they represent the most severely ill HIV-infected patients seen at our hospital with lower respiratory tract influenza infection during the 1988-1989 influenza season.
An increased susceptibility, increased severity, and/ or prolongation of influenzal illness in HIV-infected individuals might be expected. Defects in T-cell and humoral responses in these patients have been well documented, as has impaired production of interferon. Antibody response to influenza vaccination is poor, particularly as stage of HIV illness advances, and there is a selective loss of an influenza-specific, HLA-restricted cytotoxic T-lymphocyte response in persons with HIV infection. buy ortho tri-cyclen online
Data from this series of patients suggest that the course of influenza in HIV-infected patients is not markedly worsened. Given that SFGH serves approximately 700 to 800 HIV-infected patients (Martinez S, unpublished data), the small number of patients with influenzal illness severe enough to warrant evaluation for P carinii pneumonia is to some extent reassuring.


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