Effects of a Midazolam-Ketamine Admixture in Human Volunteers: RESULTS

In: Health

18 Sep 2009

Oxygen saturation levels remained high at approximately 99%. Respiration rate did not alter significantly from baseline levels throughout the study period.

Heart rate and systolic blood pressure remained stable with only a transient and minor but significant increase of 15% in heart rate and 6% in systolic blood pressure at the 10-minute mark following the bolus loading.

Diastolic blood pressure did not alter significantly from baseline levels (Figure 1).

Figure 1. Average systolic blood pressure

Figure 1. Average systolic blood pressure (solid circle) and average heart rate (solid square). Significantly different from baseline (X).

Figure 2. Average plasma catecholamines

Figure 2. Average plasma catecholamines: epinephrine (solid circle) and norepinephrine (solid square). Significantly different from baseline (X).

Plasma catecholamine levels remained stable and did not alter significantly from baseline levels except for a transient increase in epinephrine (38%) and norepinephrine (19%) 10 minutes following the bolus injections. Plasma dopamine levels remained unaltered throughout the study (Figure 2). revatio online

All subjects reported some form of dreaming, and all dreams were expressed as pleasant and never as were no cases of dysphoria or emergence-type reactions.

All of the participants were able to ambulate after the end of blood sampling, which was 30 minutes.


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