Comparison of Respiratory Effects of Two Cardioselective Beta-Blockers, Celiprolol and Atenolol, in Asthmatics: Statistical Procedures

In: Asthma

7 Oct 2014

Comparison of Respiratory Effects of Two Cardioselective Beta-Blockers, Celiprolol and Atenolol, in Asthmatics: Statistical ProceduresThese data served as an indication of the chronic day-to-day control of asthma throughout the 12-week study.
Adverse effects volunteered by patients were recorded. Study medications were returned at each visit and checked to confirm compliance.
Statistical Procedures
Data were analyzed using paired f-tests with the Bonferroni correction for multiple comparisons. Since one of the hypotheses we were testing was the hypotensive effect of these agents, any possible hypertensive effect was not considered, so that singletailed f-tests were used. Probability values less than 0.05 were considered significant.
Results
Withdrawals

Of the 12 patients initially entered, two were withdrawn. The first patient (No. 4, Table 1) was withdrawn because of severe bronchospasm associated with an upper respiratory tract infection during the placebo run-in phase, and the second patient (No. 10, Table 1) was withdrawn at the end of the first celiprolol treatment phase because of an unacceptable blood pressure rise requiring a change in therapy. However, the second patient was a severe hypertensive who had untreated blood pressure of 210/150 mm Hg, and therefore was actually incorrectly entered into the trial. The data from both patients were excluded from the analysis, since they had not completed active therapy. canadian family pharmacy online

Adverse effects were mild and most occurred during the placebo phase. Two patients complained of tiredness and mild ankle swelling, and another had headaches while taking atenolol.
Blood Pressure and Pulse Rates
All diastolic blood pressures fell significantly during both celiprolol and atenolol treatment, but systolic blood pressure taken with the patient in a supine position was reduced only by atenolol therapy (Table 2). Mean diastolic blood pressure values during the two treatment periods were similar. Five patients who were taking celiprolol and four who were taking atenolol achieved ideal diastolic blood pressure values (below 90 mm Hg or a reduction of more than 10 mm Hg).
There was a small fall in pulse rate in both the supine and erect positions when a patient who had been receiving placebo was switched to atenolol. No pulse rate change occurred during celiprolol therapy.
Table 2—Effect of Celiprolol Compared with Atenolol and Placebo on Blood Pressure of Ten Asthmatic Patients with Hypertension after 4 weeks cf Therapy

Supine Position Erect Position Pulse Rate (beats per minute)
Systolic Diastolic Systolic Diastolic Blood Pressure Blood Pressure Blood Pressure Blood Pressure Supine Erect (mm Hg) (mm Hg) (mm Hg) (mm Hg) Position Position
Placebo 160 ±5 100 ±1 147 ±4 101 ±2 78.0 + 3.7 81.6 + 3.7
Celiprolol 154±7 93±4t 146± 7 95±4|| 79.6±2.8 81.2 + 3.3
Washout** 157 ± 7 98 ±5 151 ±5 99±4 … …
Atenolol 151 ±5t 94±3§ 144 ± 4 94 ±21 67.8 ± 2.7 73.2 ±2.2

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